Department of Chemistry and Biochemistry-Spring 2017

Unless noted otherwise, All Friday Seminars will begin at 3:10 pm and take place in the Byker Auditorium-Chemistry Biochemistry Building.

January 2017

Friday, January 13

Dr. James Crawford (Genetech) will present "Discovery of GDC-0853: A Highly Potent, Selective, and Non-Covalent Btk Inhibitor." Byker Auditorium at 3:10. Professor Matt Cook will host.

Friday, January 27

Garrett Moraksi, Research Scientist in the Department of Chemistry and Biochemistry (MSU) will present "To Be or Not To Be—That is the Congestion Discovery and Development of ND-10885 as an Anti-Tuberculosis Treatment."  Byker Auditorium at 3:10 pm

February

Friday, February 3

Dr. Tim Kowalczyk, Assistant Professor in the Department of Chemistry, Advanced Materials Science and Engineering Center, and Institute for Energy Studies at Western Washington University will present "Photoactive Organic Materials Design".  Byker Auditorium at 3:10 pm.  Professor Robert Szilagyi will host.

Abstract: Revolution is afoot in the computational design of functional materials. Thanks to collective investments in fast electronic structure codes and chemical informatics tools, computational screening and design of materials to meet certain performance criteria are increasingly within reach. This talk describes our efforts to include excited-state properties explicitly in the computational screening and design of photoactive organic materials for solar energy conversion. We introduce a fast, approximate density-functional tight-binding approach for excited states (ΔDFTB) and describe its application to the prediction of Stokes shifts of organic chromophores. We then examine how electronic structure-based modeling of chromophores embedded/encapsulated in nanostructured materials, including covalent organic frameworks and aluminosilicates, can lead to design rules for further optimization of the material's desired photoactivity.

Friday, February 10

Dr. Daniel Raftery from the University of Washington will present "New Methods in Metabolomics and Applications to Colon Cancer."  Byker today at 3:10 pm Professor Valerie Copie will host.  

Abstract:

The high complexity inherent in biological samples provides a challenging analysis problem for the field of metabolomics, especially for NMR. Ideally, broad metabolome coverage provides the opportunity for deep insights into biological problems, while excellent quantitation allows high reproducibility, improved modeling capabilities, and an ability to compare across studies.  However, these goals are difficult to achieve on a routine basis because the highly complex sample matrix often precludes reliable measurements of many metabolites and complicates quantitation efforts.  As a result, many researchers including us are increasingly using MS for metabolomics studies. However, NMR has an inherent advantage in quantitation.  We have evaluated a simple protein precipitation procedure that allows the absolute quantitation of over 70 blood metabolites using a single standard compound.  These metabolites, including some at even sub-micromolar concentrations, span a broad range of classes and pathways, including organic and amino acids, as well as energy metabolites and co-enzymes.

In the second part of the talk I will discuss the biomarker discovery process in the context of colon cancer diagnosis using conventional and novel targeted MS approaches. We are also investigating an alternative statistical approach called “seemingly unrelated regression” or SUR, which was originally derived over 50 years ago in the context of econometrics.  Here, we use SUR to model metabolite levels based on the (large) effects of various clinical and environmental factors.  The results have several important implications for biomarker efforts going forward.  The application of the new methods for biomarker discovery for colon cancer will also be discussed. Such efforts promise to broaden the capabilities of NMR based metabolomics.

Friday, February 17

Dr. Xi Chu from the University of Montana, Department of Chemistry, will present “DFT and TDDFT for transition metal atoms, complexes, and more.”  Today at 3:10 pm in the Byker Auditorium.  Professor Erik Grumstrup will be the host for Dr. Chu.

Friday, February 24

Assistant Professor Matt Queen (MSU Billings)

March 

Friday, March 3

Dr. Ryan Looper (Utah). Professor Matt Cook host.

Friday, March 10

Kopriva Graduate Student Seminar- Arianna Celis-Luna

Friday, March 17- Spring break

Tuesday March 21

Dr. John Kiely  4 - 4:30 pizza reception

 4:30 Seminar: Basic Quinolone Chemistry and Biology, and What to Expect as You're Entering a Career in Science

Friday, March 24-

Professor Dipa Kalyani (St. Olaf, Minnesota). Professor Sharon Neufeldt is the host.

Friday, March 31

Emily Weinert (Emory University).  Professor Jen DuBois

April

Friday, April 7-

Annelise Barron from Bioengineering at Stanford--Mary Cloninger Host

Friday, April 14 -University Holiday

Friday, April 21 

Dr. Larry Overman, Distinguished Professor of Chemistry, University of California-Irvine is the College of Letters and Science Distinguished Lecturer and a guest of Professor Mary Cloninger.  Dr. Overman will present "Fragment Coupling and Constructing Quaternary-Carbon Stereocenters Using Carbon Radicals."

Friday, April 28

The Departments of Microbiology and Chemistry and Biochemistry will host Vadim Gladyshev (MIT)- Procrastinator 3:10 pm

 

Department of Chemistry and Biochemistry-Fall 2017

Friday September 1st

Brian Hoffman - Professor Joan Broderick host

Friday September 8 

Dr. Leslie Murray - Professor Jen DuBois host

Friday September 15

Dr. Ron Shen - Graduate Student Association host

Friday September 22

Dr. Gerrick Lindberg - Professor Sharon Neufeldt host

Friday September 29

 Catherine Murphy - Professor Tim Minton host

Friday, October 6

John Kozarich of ActivX Biosciences, Joan Broderick host