Research in the Bothner lab is directed toward understanding biological function by
investigating systems. This research takes us from the atomic scale provided by high
resolution structural models of viruses to the complex interaction networks of nucleic
acids, metabolites, and proteins that make up a living system. A diverse set of analytical,
biophysical, biochemical, and cell biology techniques are used in the discovery process.
Research interests include the assembly and stability of virus particles, extremophiles,
metabolomics, proteomics, and transcriptomics. Specific projects under investigation
are a system-wide analysis of the cell cellular response to stress of Sulfolobus solfataricus,
metabolomic analysis of hemorrhagic shock, novel anti-Hepatitis B compounds, the use
of Adeno Associated virus in gene therapy, systems biology of Ignicoccus-Nanoarchaeum
The Bothner lab is part of the Center for Bio-Inspired Nanomaterials and the Thermal Biology Institute.
Proteomics, Chemical Biology, Biophysical, Biochemistry