The evaluation of dendrimer properties is another area of macromolecular chemistry that is of interest to us. To study the relative locations and the dynamic nature of dendrimer endgroups, we have functionalized dendrimers with varying amounts of spin-labels. EPR spectra of TEMPO-labeled G(4)-PAMAM dendrimers (Figure 4) suggest that termini are randomly distributed on heterogeneously-functionalized dendrimers. Additional EPR studies with other generations of dendrimers and with non-random surface spin-labeling distributions are underway.
Chemical Biology, Organic, Spectroscopy, Structure, Synthesis