teintze

Contact Information

Office: Room 218 

Lab: Room 158 

Chemistry and Biochemistry Building
P.O. Box 173400
Bozeman, MT 59717

Phone: 406-994-5390

Fax: 406-994-5470

Email: mteintze@montana.edu

Research Group Website

 

Education

  • B.S.: 1976 Caltech
  • Ph.D.: 1981 U.C. San Diego
  • Postdoc.: 1981-82 University of Gottingen, Germany
  • Postdoc.: 1983-85 SUNY Stony Brook, NY

Courses

  • BCH 444 BIOCHEMICAL METHODS IN MOLECULAR BIOLOGY
  • MEDS 514 MOLECULAR & CELLULAR BIOLOGY

Awards and Professional Activities

  • 1983-85: National Research Service Award (NIH)

Design of small-molecule CXCR4 antagonists for HIV and cancer treatment

CXCR4 is a G-protein coupled receptor for the chemokine CXCL12 (SDF-1), which is involved in cell migration and proliferation. It is also a co-receptor used by the X4 strains of HIV, which predominate at later stages of infection, and is required for their entry into target cells. We are designing and synthesizing non-peptide small molecule inhibitors of CXCR4 based on modeling studies. Lead compounds that compete with known CXCR4 antagonists, such as the peptide T-140, are being investigated for their ability to inhibit HIV infection in vitro, and to inhibit tumor cell metastasis in vitro and in a mouse model.

Keywords:

Biochemistry

Development of broad-spectrum antibacterial compounds

Compounds with multiple biguanide groups such as chlorhexidine, alexidine, and PHMB are used as topical antimicrobials in a variety of settings. We have synthesized a series of small molecules with guanide, biguanide, and arylguanide functional groups that have comparable broad spectrum antibacterial activity, but lower cytotoxicity towards mammalian cells. We are investigating their mechanism of action and further optimizing their structures.

Keywords:

Biochemistry

Recent Publications

Wilkinson, R.A., Pincus, S.H., Shepard, J.B., Walton, S.K., Bergin, E.P., Labib, M.E. and Teintze, M. (2011) Novel compounds containing multiple guanide groups which bind the HIV co-receptor CXCR4. Antimicrob. Agents Chemother. 55:255-263. PMID: 20937786 PMCID: PMC3019677

Wilkinson, R.A., Pincus, S.H., Song, K., Shepard, J.B., Weaver, A., Labib, M.E., and Teintze, M. (2013) Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV infection. Bioorg. Med. Chem. Lett. 23:2197–2201. PMID: 23434419 PMCID: PMC3624624

Shepard, J.B., Wilkinson, R.A., Starkey, J.R. and Teintze, M. (2014) Novel Guanide Substituted Compounds bind to CXCR4 and Inhibit Breast Cancer Metastasis. Anti Cancer Drugs 25(1):8-16. doi: 10.1097. PMID: 24045366 PMCID: PMC3624624

Weaver, A.J., Shepard, J.B., Wilkinson, R.A., Watkins, R.L., Walton, S.K., Radke, A.R., Wright, T.J., Awel, M.B., Cooper, C., Erikson, E., Labib, M., Voyich, J.M. and Teintze, M. (2014) Antibacterial activity of THAM trisphenylguanide against Methicillin-resistant Staphylococcus aureus. PLoS One 9(5): e97742. doi:10.1371/journal.pone.00977

 
pubmed logoWOS logo